Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 2.5-point favorites, according to the latest 49ers vs. Texans odds. The over/under for total points scored is 42. The Texans are -151 money line favorites (risk $151 to win $100),

A week after the 49ers earned a 20-10 prime-time home win over the Atlanta Falcons, the Niners’ shorthanded defense was on the field for more than 40 minutes, in part because of the struggles of the offense, in a 26-15 road loss to the Houston Texans on Sunday.

San Francisco 49ers TE George Kittle and QB Mac Jones showcased flashes of playmaking during the loss to Houston, highlighted key connections, and reflected on areas to improve as the offense looks to rebound next week.

San Francisco 49ers quarterback Mac Jones locates tight end George Kittle for a 17-yard sliding grab against the Houston Texans.

Jones is 3-1 as a fill-in starter for San Francisco, has had 142 receiving yards in each of his last two games.

San Francisco 49ers QB Mac Jones fired a strike to WR Kendrick Bourne, moving the chains with an 18-yard gain vs. the Texans.

San Francisco 49ers wide receiver Jauan Jennings can't hold on to a deep pass attempt from quarterback Mac Jones against the Houston Texans.

The Texans face the 49ers in a virtual must-win game for their playoff hopes. We'll have updates and anlysis throughout the day from NRG Stadium.