After Melissa moves away from Jamaica, Cuba is next in line for the powerful hurricane’s fury. Landfall is expected very early Wednesday morning, likely a couple hours after midnight, but impacts have already begun.

Cuba’s president, President Miguel Díaz-Canel, warned residents to brace for a “very difficult night” as the island prepared for Hurricane Melissa to make landfall early Wednesday.

Cuba is bracing for Hurricane Melissa as it heads towards Santiago de Cuba, the island’s second-largest city, threatening catastrophic damage at a time the government is already failing to provide the most basic services and thousands are sick because of the rise of mosquito-transmitted diseases and other illnesses linked to poor sanitary conditions.