The Bills have tried to follow the Eagles blueprint to beating Mahomes by beefing up their front four. They signed Joey Bosa in free agency this offseason, extended edge rusher Gregory Rousseau and used their first five draft picks on defense, including three along the defensive line ( T.J. Sanders, Landon Jackson, Deone Walker ).

Patrick Mahomes and the Kansas City Chiefs couldn’t secure a fourth consecutive win, falling to 5-4 on the 2025 NFL season after a 28-21 loss to Josh Allen and the Buffalo Bills in Week 9. Mahomes had one of his worst games of the year, completing 15-of-34 passes (44.1%) for 250 yards and an interception, adding another five yards on the ground.

During his postgame press conference, Chiefs QB Patrick Mahomes reacted to the unreviewable intentional grounding call vs. Bills | @EdEastonJr

The NFL announced its decision on a potential punishment on a play involving Kansas City Chiefs quarterback Patrick Mahomes.

The MVP race is wide open, with each member of the "FOX NFL Kickoff" crew picking a different frontrunner for MVP.

treated the pregame tunnel walk like another costume reveal. Last week, Hollins showed up to Gillette Stadium in an inflatable chess piece costume. This time, he arrived as "Militia Mack" -- and even wore shoes, which is a stark change from his usual barefoot look.

Kansas City is a two-point favorite in the latest Chiefs vs. Bills odds from SportsLine consensus, while the over/under for total points scored is 52.5. The Chiefs are -131 money line favorites (risk $131 to win $100),