Does using alcohol, nicotine, or cannabis engender addiction by changing the structure of brains, or does the structure of brains incline some people toward using those substances? In standard brain ...

Researchers at Kanazawa University identified dopamine-driven neural mechanisms of motivation in a mouse model of behavioral addiction, offering insights into treatment. Assistant Professor Naoya ...

People with substance use disorder—whether addicted to alcohol, cocaine, heroin, or nicotine—share a strikingly similar pattern of abnormal brain connections, particularly within the brain’s reward ...

Remarkable scientific progress over the past five decades has helped us develop knowledge of how drugs of abuse induce pleasure, reinforce use, and lead to the compulsive self-administration we call ...

Researchers at the University of California San Diego have completed a massive genetic study that identifies key biological drivers of cocaine addiction, uncovering a potential new target for ...

For decades, my colleagues and I advanced the premise that early substance use—nicotine, alcohol, or cannabis (or other addicting drugs)—interferes with critical maturation stages, particularly ...

Addiction is one of the most common and consequential chronic medical conditions in the United States. Nationwide, more than 46 million people met the criteria for a substance abuse disorder as of ...