Cell division and PLK1: a three-stage activation process. The PLK1 protein plays a central role in cell division, and its dysregulation is associated with numerous cancers. Howeve ...

During cell division, a safety mechanism called the NoCut checkpoint helps delay the final stages of division when DNA bridges are present. The researchers found that this delay allows ESCRT-III ...

If measured from beginning to end, the DNA in our cells is too long to fit into the cell's nucleus, explaining why it must be constantly folded and packaged. When it is time for cell division, and the ...

For successful cell division, chromosomal DNA needs to be packed into compact rod-shaped structures. Defects in this process can lead to cell death or diseases like cancer. A new study has shown how ...

Sarah J. Aitken is at the Center of Molecular and Cellular Oncology, Yale Cancer Center, New Haven, Connecticut 06511, USA, and in the Department of Pathology, Yale School of Medicine, New Haven. Read ...

DNA replication in eukaryotic cells is a highly coordinated, multi-step process that ensures precise duplication of the genome prior to cell division. In late mitosis and early G1 phase, the Origin ...