This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

Chemical changes to histones, the proteins that help to pack and organize DNA inside cells, play a key role in determining what genes will be consistently activated over the course of an animal or ...

Acquired resistance to anticancer drugs is commonly observed in most cancer types and is caused by both genetic and epigenetic intratumoral heterogeneity. Intratumoral heterogeneity refers to the ...

Histone modifications demarcate chromatin states and orchestrate genome regulation, often in a cell-type-specific manner. Profiling histone modifications at single-cell resolution has made ...

Fruit ripening is a tightly coordinated process driven by both hormonal and environmental factors, yet the epigenetic mechanisms controlling this process remain unclear. Histone modifications, known ...

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the next generation. Now, researchers from Kyushu University have demonstrated ...

Every cell type in the human body carries the same approximately 3.2 billion base pairs of DNA, yet a liver cell behaves nothing like a neuron. The epigenome explains this difference: in each cell, ...

In a recent study published in the journal Science Advances, a group of researchers investigated the role of histone modifications in human aging by developing and evaluating histone-specific age ...