CI denotes confidence interval, and SNP single-nucleotide polymorphism. Sequencing reads were aligned to the hg19 reference genome. A SIFT (sorting intolerant from tolerant) score of less than 0.05 ...

A new phase II clinical trial finds the drug ILT-101 (also known as aldesleukin or the brand name Proleukin®) is safe and beneficial for people with lupus. ILT-101 is a low-dose human recombinant ...

Interleukin (IL)-1 is a prototypic proinflammatory cytokine. It is produced by numerous cell types (i.e., macrophages, synoviocytes, endothelial cells, chondrocytes, osteoclasts) and is found in ...

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family ...

Interleukins (ILs), a group of cytokines, are produced by leukocytes and non-immune cells like endothelial, fibroblasts, smooth muscle, epithelial and bone marrow cells. 1 ILs mainly act as ...

A pleiotropic cytokine central to the regulation of T-cell responses, interleukin 2 (IL-2), plays an essential role in a huge range of other immune modulatory actions. Image Credit: Sino Biological ...

Interleukin-6 (IL-6) is a pleiotropic cytokine that may play a role in the regulation of various aspects of the immune response, inflammation, hematopoiesis, and bone metabolism. IL-6 acts by binding ...