Stretching protein samples in all directions pulls molecules farther apart, allowing them to be visualized using only light ...

In biology, seeing can lead to understanding, and researchers in Professor Edward Boyden's lab at the McGovern Institute for Brain Research are committed to bringing life into sharper focus. With a ...

A new microscopy method enables researchers to visualize the activity of the enzymes caspase-3 and alkaline phosphatase in various biological samples (Nat. Methods 2024, DOI: ...

uiPSF is a toolbox to measure point spread functions based on inverse modeling that improves single-molecule localization microscopy (SMLM) localization and microscope characterization, and that works ...

Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail. Jacques Dubochet, former group leader at EMBL, shared the 2017 ...

Living bone is fascinating because of its unique ability to adapt to mechanical stress and regenerate without scarring. During fracture healing, blood vessels and bone cells work closely together to ...

A new variant of expansion microscopy that is tailored for brain pathology samples reveals cells and structures that can’t be seen with other methods. Expansion microscopy is a way of achieving the ...

Imagine building a traffic surveillance camera that could detect trouble-making cells speeding around in your brain before their cellular gang could commit "crimes." Most importantly, this camera ...

Confocal microscopy is a specialized fluorescence imaging technique that scientists use to acquire images at greater resolution than conventional microscopy. 1 In addition to scanning the lateral x ...

Researchers have adapted a class of techniques employed in astronomy to unblur images of far-away galaxies for use in the life sciences, providing biologists with a faster and cheaper way to get ...

In this article, we look at some of the key developments of various microscopy techniques over the last few years and how they have benefitted different areas of research and development. The impact ...

A new microscope method reveals details that were difficult to see before, helping researchers study proteins, cells, and ...