Nature

Comprehensive profiling of clinically approved kinase inhibitors reveals mutation-specific inhibitors and opportunities for drug repurposing

Protein kinases are central to cell signaling and key drug targets in cancer. To inform potential repurposing of kinase inhibitors, we profiled 86 of the ~100 approved kinase inhibitors against 758 ...
Nature

Inhibition Mechanisms of α-Glucosidase in Diabetes Management

α-Glucosidase is a key enzyme in the final step of carbohydrate digestion, cleaving terminal glucose residues from oligosaccharides at the intestinal brush border. Inhibition of this enzyme delays ...