The San Francisco 49ers (7-4) host the Carolina Panthers (6-5) on Monday Night Football in a key battle for NFC playoff positioning.

The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

At 6-5 with a playoff berth within reach, the Carolina Panthers roll into primetime carrying equal parts urgency and belief. Across the field, the 7-4 San Francisco 49ers enter Monday night trying to steady themselves after an uneven stretch,

Preview the San Francisco 49ers' NFL Week 12 matchup with the Panthers, including live stream, TV channel, odds, and game information.

The San Francisco 49ers are back at Levi’s Stadium in Week 12 of the NFL season with a “Monday Night Football” matchup set against the Carolina Panthers.

The NFL season continues in Week 11 when the San Francisco 49ers host the Arizona Cardinals on Sunday. Start time, how to watch, streaming and NFL schedule.