Clin Drug Invest. 2007;27(8):509-531. Because of its poor tolerability, regimen complexity and drug-interaction potential relative to other new NRTIs, use of didanosine has decreased over the last few ...

On Monday, Dr. Michio Hirano, a neurologist at Columbia University, will evaluate 11-month old Charlie Gard, the British boy who is on life support because of a rare, lethal disease called ...

DNA, often called the blueprint of life, is built from four chemical building blocks known as deoxy-nucleoside triphosphates (dNTPs)—dATP, dTTP, dGTP, and dCTP. Cells constantly need these molecules ...

Nucleoside derivatives have important therapeutic activity in chronic lymphocytic leukaemia (CLL). Experimental evidence indicates that in CLL cells most of these drugs induce apoptosis ex vivo, ...

Acyclic nucleoside phosphonates (ANPs) represent a vital class of compounds with significant applications in antiviral and antiparasitic therapy. Characterised by a non-hydrolyzable phosphonate group, ...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), identified as the causative agent of the COVID-19 (coronavirus disease 2019) pandemic, was first detected in Wuhan, China late December ...

Obeldesivir (GS-5245), a novel investigational small molecule oral antiviral, represents a new tool in the ongoing effort to prepare for future pandemics. Several researchers at the University of ...

Analysis of Factors That Correlate With Mucositis in Recipients of Autologous and Allogeneic Stem-Cell Transplants PURPOSE: The nucleoside analogs fludarabine, 2′-deoxycoformycin (DCF), and ...

Charlie's parents wanted to take the 11-month-old baby to the US against the wishes of doctors in a bid to save his life THE world was touched by the case of Charlie Gard as his parents fought a ...

The coronavirus disease 2019 (COVID-19) pandemic has infected around 225 million people and claimed more than 4.64 million lives worldwide. This pandemic is caused by severe acute respiratory syndrome ...

Acute lymphoblastic leukemia is the most common type of childhood leukemia, with about 5,000 children diagnosed in the U.S. each year. Now researchers have synthesized a nonnatural deoxynucleoside ...

Regimens containing three nucleoside reverse-transcriptase inhibitors offer an alternative to regimens containing nonnucleoside reverse-transcriptase inhibitors or protease inhibitors for the initial ...