NFL Week 13 odds, picks, predictions, TV channel, streaming information for the Sunday football game between San Francisco 49ers and Cleveland Browns.

Everything you need to know about the NFL match between Cleveland Browns and San Francisco 49ers, as well as kick-off time and team news

Find single game tickets to the San Francisco 49ers vs. Cleveland Browns NFL Week 13 matchup on Sunday, November 30, 2025 at Huntington Bank Field.

Get the full 49ers practice and media schedule ahead of Week 13 vs. the Browns, including press conferences with Shanahan, Saleh, and Purdy

With a win tonight, the 49ers’ odds of making the playoffs move from 83 percent from 89 percent in The Athletic’s NFL Playoff Simulator. With the Rams firmly atop the NFC West (and, now, the entire NFC), San Francisco is overwhelmingly likely to make the playoffs as a wild-card team.

In the second half, Purdy and Co. settled down, extending their lead with an 80-yard touchdown drive in the early stages of the third quarter. Christian McCaffrey was the one to find the end zone at that juncture, scoring from 12 yards out against his former team as he squared off against them for the first time since being traded in 2022.

We're diving into every matchup in Week 13 of the 2025 NFL season â?? including key storylines, matchups to watch, and injury news. The Green