DNA sequence assembly is a process that involves aligning and merging fragments of a DNA sequence to reconstruct the original structure of the DNA. This is an essential step of the genome analysis ...

Through a combination of high-throughput sequencing, high performance computing, and genetic mapping, DOE JGI researchers have derived a sequence assembly for the highly repetitive plant genome of ...

Recombination-based DNA construction methods, such as Gibson assembly, have made it possible to easily and simultaneously assemble multiple DNA parts, and they hold promise for the development and ...

Individual sequence reads generated in a whole-genome shotgun-sequencing project are initially assembled into sequence contigs. Groups of sequence contigs are then organized into scaffolds on the ...

GPhase, a new haplotype-resolved scaffolding algorithm, jointly leverages assembly graphs and 3C signals to construct ...

This chapter addresses the question of generating a good assembly sequence for a product. [1] The mathematics of assembly sequence analysis and the data models needed to support it take their form ...