Christian McCaffrey was the engine of the 49ers offense in 2023. After winning Offensive Player of the Year, McCaffrey was ...

San Francisco running back Isaac Guerendo was injured and carted off early during the 49ers' season finale versus the Arizona Cardinals. On San Francisco's opening series and on Guerendo's second ...

Unfortunately, San Francisco 49ers' running back Isaac Guerendo was carted off the field early in the first quarter.

Rookie running back Isaac Guerendo was carted off the field less than two minutes into the first quarter during the 49ers’ season finale in Arizona against the Cardinals with a leg injury.

San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the Lions.

Coach Kyle Shanahan said after Sunday's 47-24 loss to the Cardinals that Guerendo (knee/ankle) likely suffered an MCL sprain and will undergo further testing Monday, Lindsey Pallares of the 49ers ...

San Francisco 49ers running back Isaac Guerendo is expected to play Monday night against the Detroit Lions, according to ESPN's Adam Schefter. Guerendo has been limited in practice this week ...

Coach Kyle Shanahan said Monday that the 49ers expect Guerendo (foot/hamstring) to practice Thursday, Nick Wagoner of ESPN.com reports. Guerendo picked up foot and hamstring injuries in Week 15 ...

San Francisco 49ers running back Isaac Guerendo gave a positive update on his knee injury Monday, noting he did not tear his ACL as some had speculated: ACL is good, thank you GOD. I'll be back ...

A first-round tender would cost the 49ers an estimated $7,279,000 for the 2025 season according to Over the Cap. The ...

The San Francisco 49ers are making a final push to close out a lost season on a strong note. Injuries have decimated the reigning NFC champs. Isaac Guerendo, however, provided a promising update.

SANTA CLARA, Calif. -- After missing last week because of a hamstring injury, San Francisco 49ers running back Isaac Guerendo is set to play Monday night against the Detroit Lions. Guerendo ...