San Francisco 49ers wide receiver Jauan Jennings can't hold on to a deep pass attempt from quarterback Mac Jones against the ...

Texans head coach DeMeco Ryans is a former 49ers defensive coordinator under Kyle Shanahan, so San Francisco knows how ...

Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 2.5-point favorites, according to the latest 49ers vs.

The redemption arc of quarterback Mac Jones was fun while it lasted, but the San Francisco 49ers need starting QB Brock Purdy ...

San Francisco 49ers QB Mac Jones fired a strike to WR Kendrick Bourne, moving the chains with an 18-yard gain vs. the Texans.

San Francisco 49ers TE George Kittle and QB Mac Jones showcased flashes of playmaking during the loss to Houston, highlighted ...

A week after the 49ers earned a 20-10 prime-time home win over the Atlanta Falcons, the Niners’ shorthanded defense was on ...

The 49ers offense sabotaged the defense and the defense failed to set up the offense in one-sided loss to Texans.

In Houston’s second offensive drive, rookie running back Woody Marks made another highlight-reel play. On second & 5, ...