Lupus Science & Medicine

Harnessing AI and social media to understand real-world patient experiences in SLE

Objective To apply large language models (LLMs) to Reddit posts referencing SLE to identify patient-expressed unmet medical ...
Lupus Science & Medicine

Prevalence and clinical associations of cerebral atrophy in systemic lupus erythematosus

Objectives To determine the prevalence of cerebral atrophy in a multi-ethnic systemic lupus erythematosus (SLE) cohort and to ...
Lupus Science & Medicine

Integrated immune profiling identifies a coordinated T-cell activation and inflammatory signature in SLE

Introduction Patients with SLE have an increased risk of infections and infection-related mortality, which may be associated ...
Lupus Science & Medicine

International development of a lupus-specific instrument to assess cognitive symptoms in patients with SLE: Lupus Brain Fog Severity Scale (LBFSS) study

Introduction Cognitive symptoms such as ‘brain fog’ are frequent and disabling in patients with SLE. We aimed to develop and ...
lupus.bmj

Phase Ib, multicentre, open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of subcutaneously administered ...

Objective To determine the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of subcutaneously administered mosunetuzumab, a CD20xCD3 T-cell-engaging bispecific antibody, in ...
lupus.bmj

Stage-resolved mapping of RP105 (CD180)-negative B cells reveals residual plasmablast-lineage skewing in SLE: a cross-sectional study

Objective To determine whether clinically inactive/low-activity SLE reflects immunological remission in this cross-sectional study using CD180 (RP105)-anchored, stage-resolved profiling of peripheral ...
lupus.bmj

Antiphospholipid antibody associated retinal microvascular impairment: a case report and literature review

Ocular involvement in antiphospholipid syndrome typically manifests as retinal artery or vein occlusions. Isolated progressive retinal microvascular impairment as associated with antiphospholipid ...
lupus.bmj

Comparison of BAFF and type I IFN activity in blood and placenta in SLE and healthy pregnancies

Objective To examine B cell-activating factor (BAFF) and type I interferon (IFN) activity at the transcriptional and protein levels in blood and placental tissue in SLE compared with healthy ...
lupus.bmj

Unsupervised clustering of clinical and laboratory features of systemic lupus erythematosus: insights from a multicentre cohort

Objective This study explored the relationship between clinical phenotypes and immuno-molecular features of systemic lupus erythematosus (SLE) using unsupervised machine learning and multi-omics ...
lupus.bmj

Efficacy and safety of anifrolumab in patients with systemic lupus erythematosus without prior immunosuppressant use: post hoc analysis of phase 3 TULIP-1 and TULIP-2 trials

Objective Although current treatment recommendations for systemic lupus erythematosus (SLE) provide the option for biologic agents without prior failure of immunosuppressants (IS), data on this ...
lupus.bmj

PT4:06 Four-year safety and efficacy of deucravacitinib in systemic lupus erythematosus: results from the phase 2 PAISLEY SLE trial

Objectives Effective, well-tolerated therapies are needed for SLE. Deucravacitinib is an oral, selective tyrosine kinase 2 (TYK2) inhibitor under evaluation in phase 3 SLE studies. Deucravacitinib ...
lupus.bmj

Significant glomerular IgM deposition predicts poorer kidney outcomes in lupus nephritis compared with other forms of immune complex deposits

Objective Glomerular immune complex deposition plays a central role in lupus nephritis (LN), but the prognostic relevance of individual immunoglobulin components remains unclear. This study aimed to ...