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Cardiac Development at a Single-Cell Resolution.

Mammalian heart development is a complex process. Recent advances in using stem-cell-derived cardiac progenitor cells along with advanced genetic methods are described that will lead to a better ...
cirm.ca.gov

The cardiac conduction system: History, development, and disease.

The system in the heart that controls muscle contraction is discussed. Known diseases relating to the development of heart contraction and clinical approaches to correct defects in heart contraction ...
cirm.ca.gov

CRISPR activation for SCN2A-related neurodevelopmental disorders.

Serena Tamura, Andrew D Nelson, Perry W E Spratt, Elizabeth C Hamada, Xujia Zhou, Henry Kyoung, Zizheng Li, Coline Arnould, Vladyslav Barskyi, Beniamin Krupkin, Kiana Young, Jingjing Zhao, Stephanie S ...
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Deep learning the dynamic regulatory sequence code of cardiac organoid differentiation.

Eyal Metzl-Raz, Ryan Zhao, Salil Deshpande, Jackson Powell, Elizabeth G Porter, Yassine Zouaghi, Betty B Liu, Samuel H Kim, Immanuel Abdi, Ivy Evergreen, Megha Agarwal, Maya U Sheth, Joshua Rico, ...
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A human-specific regulatory mechanism revealed in a pre-implantation model.

Pre-implantation events in human development are difficult to study due to ethical concerns. This work utilizes a human stem-cell-based blasted model to test the genetic regulation of implantation ...
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Researcher Resources

CIRM provides funding across all stages of research, from basic science to translational studies and clinical trials. This support drives best-in-class research aimed at developing innovative ...
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Industry Alliance Program

CIRM established the Industry Alliance Program (IAP) as a direct opportunity for the industry to partner with CIRM in accelerating the most promising stem cell, gene, and regenerative medicine therapy ...
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Our Review Process

At CIRM, we aim to keep our grant funding process as simple, clear, and thorough as possible. This guide provides an overview of the process, with links to learn more and contact information for CIRM ...
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Industry Resource Partners (IRP)

The CIRM Industry Resource Partners (IRP) Program forges beneficial partnerships between industry organizations and CIRM awardees to stimulate innovation and accelerate the development of novel ...
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鸟类内耳感觉毛细胞再生的解剖学和分子生物学见解。

与哺乳动物不同，鸟类能够再生内耳毛细胞，修复听力损伤。为了将鸟类修复听力的机制应用于人类，比较鸟类和哺乳动物内耳毛细胞的叫声将有助于我们找到修复人类听力损伤的方法。
cirm.ca.gov

CIRM学者培训计划

研究发育过程中心脏缺陷的遗 传原因十分困难。本研究描述了如何利用干细胞衍生的心脏类器官来探索心脏发育早期阶段的基因表达，从而识别可能与先天性心脏病相关的基因。这项研究将 ...
cirm.ca.gov

唐氏综合征患者皮质神经发生速度加快。

唐氏综合征（DS）由21三体综合征（TS21）引起，是导致智力障碍的最常见遗传病因(1,2)。DS的神经系统影响首先在产前发育阶段显现，表现为放射状胶质细胞（RG）神经干细胞增殖减少、皮质体积 ...