Down 16-0, the 49ers came alive with last-minute theatrics before halftime, highlighted by Kittle’s 17-yard, third-down touchdown catch. Setting up that score was Brian Robinson’s 46-yard kick return – the 49ers’ longest this season – plus a 15-yard facemask penalty, followed by an 18-yard catch from Kendrick Bourne.

Without even setting foot on the field in Week 8, the Seattle Seahawks have moved into first place in the NFC West. As the end of October quickly approached, a three-team logjam formed atop the NFC West.

For the first time in nearly a year, the 49ers defense has notched an interception, ending an NFL record-long drought.

The San Francisco 49ers have already lost linebacker Fred Warner to a long-term injury, and now they may have lost another player at the position.

The key is Jones beating the pass rush. The Houston defense is built around its front four getting pressure. Take that away and the 49ers can build long sustained drives and convert in the red zone against this defense. McCaffrey should have success on the ground, but could be limited in the air.

The San Francisco 49ers got Alfred Collins back late in the second quarter against the Texans and almost immediately lost another defensive lineman.

C.J. Stroud found Xavier Hutchinson for a 30-yard touchdown, extending the Houston Texans' lead over the San Francisco 49ers.

Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 2.5-point favorites, according to the latest 49ers vs. Texans odds. The over/under for total points scored is 42. The Texans are -151 money line favorites (risk $151 to win $100),