The 49ers have played some bad football this season. But Sunday was something else entirely: The 49ers played so poorly against the Houston Texans that it makes you question if they can ever win again. Their performance in a 29-15 loss was, in a word, awful.

The San Francisco 49ers endured a three-hour root canal Sunday that served as a reminder that things can get really ugly when potential first-ballot Hall of Famers are replaced by second-stringers.

Amidst all the injuries the 49ers are dealing with, fans are hoping they make a trade to bring in a reinforcement or two.

The Texans face the 49ers in a virtual must-win game for their playoff hopes. We'll have updates and anlysis throughout the day from NRG Stadium.

Houston Texans quarterback C.J. Stroud (7) is congratulated by teammates Aireontae Ersery (79) and Tytus Howard (71) after throwing a touchdown pass during the second half of an NFL football game against the San Francisco 49ers Sunday, Oct. 26, 2025, in Houston. Credit: AP/Eric Christian Smith

Houston Texans tight end Dalton Schultz collects quarterback C.J. Stroud's outlet pass for a 17-yard catch-and-run gain against the San Francisco 49ers. Houston Texans wide receiver Xavier Hutchinson races down the sideline following a dime over the middle from quarterback C.J. Stroud against the San Francisco 49ers.

Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 2.5-point favorites, according to the latest 49ers vs. Texans odds. The over/under for total points scored is 42. The Texans are -151 money line favorites (risk $151 to win $100),

On the Texans side, the biggest name of mention is their star wide receiver, Nico Collins, who will miss his first game of the 2025 season with a concussion he suffered in Week 7 vs. the Seattle Seahawks, and will look to make his return vs. the Denver Broncos next weekend.