USA Today's NFL experts make their picks for a Week 16 showdown between the Indianapolis Colts and San Francisco 49ers ...

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the ...

The Tennessee Titans made a few roster moves on Tuesday, placing three safeties on injured reserve and adding two defensive ...

Edge rushers and safeties dominated PFF grades. Find out who shined and where the 49ers' defense still faces challenges.

Who can you start and sit in the fantasy football playoffs? USA TODAY Sports breaks down some top options for Week 16.

When Daniel Jones went down for the season with a torn Achilles, the 49ers probably figured their upcoming game against the ...

San Francisco 49ers quarterback Brock Purdy has moved into ninth in passing yards in franchise history, surpassing Frankie ...

The San Francisco 49ers' defense is lacking playmaking and game-changing threats. Nick Bosa and Fred Warner were supposed to be those players.

The San Francisco 49ers tweaked their practice squad and opened a spot on that roster with their most recent roster move.

For the New York Giants (among others), identifying the right head coach has become an unsolvable Rubik’s Cube.

The Tennessee Titans have placed a trio of safeties on injured reserve. Tuesday's moves effectively end the seasons of Xavier ...

With three weeks left in the season, a look at the NFL Playoff picture and what teams have to do in order to make the ...